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Therapeutic Index

MYCOMUN

Each tablet contains :

 

Composition:

Mycophenolate Mofetil        ...................................................500 mg

 

Indications:

Mycophenolate is indicated for the prophylaxis of organ rejection in patients receiving allogeneic renal, cardiac or hepatic transplants. Mycophenolate should be used concomitantly with cyclosporine and corticosteroids.

 

Description:

The salvage pathway of purine synthesis in lymphocytes is less active than the de novo synthesis of purines. Inosine monophosphate is converted to guanosine monophosphate by inosine monophosphate dehydrogenase. During T-cell activation, the activity of both types I and II inosine monophosphate dehydrogenase enzymes increases by tenfold. Mycophenolate mofetil is converted in the liver by ester hydrolysis to mycophenolic acid, which in turn non-competitively and reversibly inhibits types I and II inosine monophosphate dehydrogenase activity during DNA synthesis in the S phase of the cell cycle. In the salvage pathway, guanine is converted to guanine monophosphate by the enzyme hypoxanthine-guanine phosphoribosyltransferase.

Dosage :
A dose of 1 g administered orally twice a day (daily dose of 2 g) is recommended for use in renal transplant patients or as per the physician’s advice.

Presentations:              10 tablets      
                                            
MRP          Retailer        Stockist
                                          
880.00         704.00           633.60
 
       
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