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Each tablet contais :
Composition:
Artesunate
......................................................................50
mg
Indications:
Cerebral malaria, Chloroquine resistant malaria,
Plasmodium falciparum malaria, Severe malaria.
Description:
Artesunate and its active
metabolite dihydroartemisinin are potent blood
schizonticides, active against the ring stage of the
parasite. It is effective against P. falciparum
resistant to all other antimalarial drugs. It does not
have hypnozoiticidal activity. It reduces gametocyte
carriage rate.
The functional group responsible for antimalarial
activity of artesunate is endoperoxide bond. Release of
an active oxygen species from this bond kills the
parasite if accumulated in the erythrocytic cells.
It also suppresses the production or activity of
antioxidant enzymes in the erythrocytes.
CONTRAINDICATIONS
The drug is
contraindicated in patients with prior hypersensitivity
to artesunate or artemisinin derivatives, pyrimethamine
or sulphonamides. The drug is also contraindicated in
patients with severe renal insufficiency, marked liver
parenchymal damage or blood dyscrasias, patients with
documented megaloblastic anemia due to folate
deficiency, infants < 2 months of age, pregnancy and
during the nursing period.
Dosage :
Adults: Total oral dose of 600mg is recommended which
can be divided into two tab. (100mg) bd on the first day
followed by 1 tab. (50mg) bd for next four days.
Children: Half the adult dose in the above manner.
Presentations : MRP Retailer Stockist
4 tablets 92.80 74.24 66.81
1 vial
169.95 135.96 122.36
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