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Each kit
contains:
Composition:
1 cap of
Rifampicin..........................................................100
mg
1 Tab of Pyrazinamide.....................................................300
mg
1 Tab of INH........................................................................50
mg
Indications :
Rifampicin, Ethambutol, Isoniazid, Pyrazinamide and
Streptomycin are used in medication and management of
Tuberculosis.
Description:
Rifampicin inhibits DNA-dependent
RNA polymerase
in bacterial cells by binding its beta subunit, thus
preventing transcription of
messenger RNA
(mRNA) and subsequent translation to proteins.
Pyrazinamide is a
prodrug that
stops the growth of
Mycobacterium
tuberculosis. M. tuberculosis has the
enzyme pyrazinamidase which is only active at
acidic
pH.
Pyrazinamidase converts pyrazinamide to the active form,
pyrazinoic acid. Pyrazinoic acid inhibits the enzyme
fatty acid synthetase I, which is required by the
bacterium to synthesise
fatty acids.
INH is thought to work through its effects
on lipids (fats) and DNA within the tuberculosis
bacterium.
Dosage :
Children : 10-15 mg /kg body wt. daily as single dose.
Presentations : 1kit
MRP Retailer
Stockist
6.75
5.40 4.86
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