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Each
kit contains:
Composition:
1 cap of Rifampicin..............................................450
mg
1 Tab of Ethambutol............................................800
mg
1 Tab of INH..........................................................150
mg
2 Tab of Pyrazinamide.........................................750
mg
Indications:
Rifampicin, Ethambutol, Isoniazid, Pyrazinamide and
Streptomycin are used in medication and management of
Tuberculosis.
Description:
Rifampicin inhibits DNA-dependent
RNA polymerase
in bacterial cells by binding its beta subunit, thus
preventing transcription of
messenger RNA
(mRNA) and subsequent translation to proteins.
Ethambutol is a synthetic, bacteriostatic antitubercular
agent. Ethambutol diffuses into actively growing
mycobacteria cells such as tubercle bacilli . It appears
to inhibit the synthesis of one or more metabolites,
thus impairing cell metabolism, arresting
multiplication, and resulting in cell death.
INH is thought to work through its effects
on lipids (fats) and DNA within the tuberculosis
bacterium.
Pyrazinamide is a
prodrug that
stops the growth of
Mycobacterium
tuberculosis. M. tuberculosis has the
enzyme pyrazinamidase which is only active at
acidic
pH.
Pyrazinamidase converts pyrazinamide to the active form,
pyrazinoic acid. Pyrazinoic acid inhibits the enzyme
fatty acid synthetase I, which is required by the
bacterium to synthesise
fatty acids.
Dosage:
Adults: (below 50 kg): 450 mg daily as a single dose.
More than 50 kg: upto 600 mg daily.
Children: 10-15 mg /kg body wt. daily as single dose.
Presentations: 1 kit
MRP
Retailer
Stockiest
14.10
11.28
10.15
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