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Each capsule (E.C. granules ) contains:
Composition:
Omeprazol..................................................................20
mg
Indications:
Ulcer,
duodenal; Adenoma, multiple endocrine; Esophagitis,
erosive; Gastroesophageal Reflux Disease; Mastocytosis,
systemic; Ulcer, gastric; Zollinger-Ellison syndrome;
Pregnancy Category C;
Description:
Omeprazole is a selective and irreversible proton pump
inhibitor. Omeprazole suppresses gastric acid secretion
by specific inhibition of the hydrogen–potassium
adenosinetriphosphatase (H +, K +-ATPase)
enzyme system found at the secretory surface of parietal
cells. It inhibits the final transport of hydrogen ions
(via exchange with potassium ions) into the gastric
lumen. Since the H +, K +-ATPase
enzyme system is regarded as the acid (proton) pump of
the gastric mucosa, omeprazole is known as a gastric
acid pump inhibitor. The inhibitory effect is
dose-related. Omeprazole inhibits both basal and
stimulated acid secretion irrespective of the stimulus.
Side/Adverse Effects
Note: Gastric fundic gland polyps have occurred
rarely in patients receiving omeprazole; these appear to
be benign and reversible upon discontinuance of
omeprazole.
Gastroduodenal carcinoids have been reported in patients
with Zollinger-Ellison syndrome who have received
long-term omeprazole therapy. These carcinoids are
believed to be a manifestation of the underlying
syndrome, which is known to be associated with such
tumors.
Atrophic gastritis has been noted occasionally in
gastric corpus biopsies from patient receiving long-term
omeprazole therapy.
Overt liver disease has occurred rarely, and included
hepatocellular, cholestatic, or mixed hepatitis, liver
necrosis (sometimes fatal), hepatic failure (sometimes
fatal), and hepatic encephalopathy.
The following side/adverse effects have been selected on
the basis of their potential clinical significance
(possible signs and symptoms in parentheses where
appropriate)—not necessarily inclusive:
Contraindications
Omeprazole delayed-release capsules are contraindicated
in patients with known hypersensitivity to any component
of the formulation
Dosage:
As per the physician’s advice.
Presentations: 10 caps
MRP
Retailer Stockiest
9.80
7.84 7.05
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