Each Vial 5ml contains:
Composition:
Abciximab
.....................................................................2
mg
Indications :
Platelet aggregation inhibition as adjunct to
percutaneous
transluminal coronary angioplasty or atherectomy
(PTCA).
Description:
Abciximab (c7E3) is a chimeric mouse-human
monoclonal
antibody directed against the GP IIb/IIIa
receptor; its mechanism
of action is thought to be steric hindrance of
the receptor itself as
opposed to direct binding to the RGD binding
site of the receptor.
It also inhibits the vitronectin (av
b3)receptor, which mediates
both platelet coagulation as well as endothelial
and vascular
smooth muscle cell proliferation.
Dosage:
0.25 mg/kg administered 10-60 minutes before the
start of PTCA ` followed by a continuous I.V..
Injection of
10
mcg/min. for 12 hours.
Presentations:
Vial 5ml
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