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Each
Injection contains:
Composition:
Pantoprazole
..................................................................40
mg
Indications:
Protozole reduces the amount of acid in the stomach and
duodenum. This helps to heal peptic ulcers and helps to
prevent
them from recurring. It also helps to relieve the
symptoms of
reflux
oesophagitis.
Description:
Proton
pump inhibitors act by irreversibly blocking
the
hydrogen/potassium
adenosine triphosphatase
enzyme system
(
the
H+/K+
ATPase, or more commonly just gastric
proton pump)
of the gastric
parietal cell.
The proton pump is the terminal stage
n gastric acid secretion, being directly responsible
for secreting H
+ ions into the gastric lumen, making it an
ideal target for
inhibiting
acid secretion.
Targeting the terminal-step in acid production, as well
as the
irreversible nature of the inhibition, result in a
class of drugs
t hat is significantly more effective than
H2
antagonists and
reduces gastric acid
secretion by up to 99%.
The lack of the acid in the stomach will aid in the
healing of
duodenal
ulcers, and reduces the pain from indigestion and
h eartburn,
which can be exacerbated by stomach acid. However,
lack
of stomach acid may also contribute to
hypochlorhydria,
a la
c k of sufficient
hydrochloric acid,
or HCl. Hydrochloric acid is r
equired for absorption of
nutrients, particularly calcium.
The proton pump inhibitors are given in an inactive
form. The
inactive form is neutrally charged (lipophilic)
and readily crosses
cell membranes
into intracellular compartments (like the parietal
cell canaliculus) that have acidic environments. In an acid
environment, the inactive drug is protonated and
rearranges into
its active form. As described above, the
active form will
covalently
and irreversibly bind to the gastric proton pump,
deactivating it.
Dosage: As per
the physician’s advice.
Presentation:
MRP
Retailer Stockiest
52.60
42.08 37.87 | 
