Composition:
Paracetamol I.P................................................325
mg
Ibuprofen I.P......................................................200
mg
Caffeine I.P..........................................................40
mg
Excipients..................................................................q.s.
Indications:
For fast relief from Headache, Toothache, Muscular
ache, pain, Cold Symptoms and Feverish conditions.
Description:
Paracetamol (called acetaminophen in the USA) is
a derivative of p-aminophenol, which corresponds to
the active principal metabolite phenacetin.
Its mechanism of action is not clearly established.
It appears that paracetamol inhibits prostaglandin
biosynthesis in the central nervous system
but not (or hardly) in the peripheral tissues. In
any case, paracetamol only has minimal
anti-inflammatory action compared to non-steroidal
anti-inflammatory agents.
Contraindications
Paracetamol should not be used in hypersensitivity to the
preparation and in severe liver diseases.
Special warnings and
precautions
The preparation should be used with care
in patients with liver and renal diseases. The
treatment with Paracetamol may change the laboratory
tests of uric acid and blood glucose analysis. In
severe renal failure the interval between two
consecutive takings should not be shorter than 8
hours. The treatment with the preparation is not
advisable during the first trimester of the
pregnancy. In nursing women the preparation should
be used with strictly observation of the therapeutic
dose and duration of the treatment.
Dosage: 1-2
Tablets 3 t o 4 times daily. In accordance with age
or as directed by the Physician.
Presentations: 10 tablets
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