|
Each tablet contains:
Composition:
Nimesulide.......................................................................100
mg
Diclofenac
Sodium............................................................50
mg
Indications :
Namosid -D
is indicated in musculoskeletal disorders, dysmenorrhoea,
thrombophlebitis, postoperative pain, ental and ENT
inflammation.
Description:
Nimesulide is a nonsteroidal anti-inflammatory drug (NSAID)
of the sulfonanilide class. Its anti-inflammatory,
analgesic and antipyretic activities have been
demonstrated in several widely used animal experimental
models and in numerous clinical trials. Nimesulide only
weakly inhibits prostaglandin synthesis and appears to
exert its effects through various mechanisms. It
inhibits the release of oxidants from activated
neutrophils and has a scavenging effect on hypochlorous
acid without affecting neutrophil function. Nimesulide
also decreases histamine release from tissue mast cells
and inhibits the production of platelet-activating
factor by human basophils. Furthermore, when added in
vitro to cultures of human articular chondrocytes,
nimesulide inhibits the release of stromelysin and
blocks metalloproteinase activity.
Diclofenac may also be a unique member of the NSAIDs.
There is some evidence that diclofenac inhibits the
lipooxygenase
pathways, thus reducing formation of the
leukotrienes
(also pro-inflammatory autacoids). There is also
speculation that diclofenac may inhibit
phospholipase A2
as part of its mechanism of action. These additional
actions may explain the high potency of diclofenac - it
is the most potent NSAID on a broad basis.
Dosage : Adults: 100 mg twice daily. Children: 5
mg/kg/day in 2-3 divided doses.
Presentations :
10 tablets
MRP Retailer Stockist
24.50 19.60 17.64
| 
