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Each
film-coated tablet contains:
Composition:
Sildenafil
Citrate...............................................................50
mg
Indications :
NEOGRA is indicated for the treatment of erectile
dysfunction in men.
Description:
Part of the physiological process of erection
involves the parasympathetic nervous system causing
the release of
nitric oxide
(NO) in the
corpus cavernosum
of the penis. NO binds to the receptors of the
enzyme
guanylate cyclase
which results in increased levels of
cyclic guanosine monophos phate
(cGMP), leading to
smooth muscle
relaxation (vasodilation) in the corpus cavernosum,
resulting in increased inflow of blood and an
erection.
Sildenafil is a potent and selective inhibitor of
cGMP specific
phosphodiesterase type 5 (PDE5) which is
responsible for degradation of cGMP in the
corpus cavernosum.
The molecular structure of sildenafil is similar to
that of cGMP and acts as a competitive binding agent
of PDE5 in the corpus cavernosum, resulting in more
cGMP and better erections. Without sexual
stimulation, and therefore lack of activation of the
NO/cGMP system, sildenafil should not cause an
erection. Sildenafil is
metabolised
by
hepatic
enzymes
and excreted by both the
liver and
kidneys.
If taken with a high-fat meal, there may be a delay
in absorption of sildenafil and the peak effect
might be reduced slightly as the plasma
concentration will be lowered
Contraindications
Use of
NEOGRA
is contraindicated
in patients with a
known hypersensitivity to any component of the
tablet.
Consistent with its known effects on the
nitric oxide/cGMP
pathway, sildenafil was shown to potentiate the
hypotensive
effects of nitrates, and its administration to
patients who
are concurrently using
organic nitrates in any form is
therefore contraindicated.
Dosage:
For
most patients, the recommended dose is 50 mg taken,
as needed approximately 1 hour before sexual
activity. However, NEOGRA may be taken anywhere from
4 hours to 0.5 hour before sexual activity. Based on
effectiveness and toleration, the dose may be
increased to a maximum recommended dose of 100 mg or
decreased to 25 mg. The maximum recommended dosing
frequency is once per day.
Presentations: 4
Tablets
MRP
Retailer Stockiest
60.00 One
Strip Free 54.00
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