|
Each
uncoated tablet contains:
Composition:
Misoprostol......................................................................200
mcg
Excipients..................................................................................q.s.
Indications:
Treatment of duodenal, gastric and NSAID induced ulceration.
Misobortol should be taken for the duration of NSAID
therapy.
Description:
Misoprostol is a synthetic analogue of naturally
occurring prostaglandin E1. It has been approved in more
than 90 countries for prevention and treatment of
gastric and duodenal ulcers. Very few countries have
misoprostol registered as an abortion pill. It is safe
and well tolerated, and can be kept at room temperature
when packed in aluminium blisters.
Outcome of treatment with misoprostol when used orally
or vaginally has shown a complete abortion rate of 87%
and 95%, incomplete abortion 3% and 4%, missed abortion
3% and 1% and continuing pregnancy in 7% and 1%
respectively.
Misoprostol is rapidly absorbed after oral
administration and converted to its pharmacologically
active metabolite, misoprostol acid. Plasma
concentrations of misoprostol acid peak in approximately
30 minutes and decline rapidly thereafter.
The effects of misoprostol on the reproductive tract are
increased, and gastrointestinal adverse effects are
decreased, if this is administered vaginally. On vaginal
administration, the plasma concentrations of misoprostol
acid peaks in 1-2 hours and then declines slowly.
Vaginal application results in slower increase and lower
peak plasma concentration of misoprostol acid than does
oral administration. Uterine contractility increases and
then plateaus one hour after oral administration,
whereas, contractility continues for four hours after
vaginal route.
Dosage :
The recommended adult oral dose for the treatment of
duodenal, gastric and NSAID induced ulceration is 200
mcg 4 times daily with food and at bedtime for 4-8
weeks.
If this dose is not tolerated, a dose of 100 mcg can be
used.
Presentations:
4 tablets
MRP Retailer
Stockiest
61.00 48.80
36.72
|
