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Each
tablet contains :
Composition:
Atorvastatin……….........................................
10 mg
Atorvastatin……….........................................
20 mg
Indications :
Lipirol is a prescription drug. It is used in patients
with multiple risk factors for heart disease such as
family history, high blood pressure, age ,low HDL or
smoking to reduce the risk of heart attack and stroke.
Lipirol is also used in patients with type 2 diabetes
and at least one other risk factor for heart disease
such as high blood pressure, smoking or complications
of diabetes, including eye disease and protein in urine,
to reduce the risk of heart attack and stroke.
Description:
Atorvastatin (Lipitor) is a selective, competitive
inhibitor of HMG
CoA
reductase, the rate-limiting enzyme that converts
3-hydroxy
3-methylglutaryl-coenzyme A to mevalonate, a precursor
of
sterols,
including cholesterol. Cholesterol and triglycerides
circulate in the bloodstream as party of lipoprotein
complexes.
With
ultracentrifugation, these complexes separate into HDL
(high-density lipoprotein), IDL (intermediate-density
lipoprotein),
LDL
(low-density lipoprotein), and VLDL (very-low-density
lipoprotein) fractions.
Triglycerides (TG) and cholesterol in the liver are
incorporated into
VLDL and
released into the plasma for delivery to peripheral
tissues.
LDL is formed from VLDL and is catabolized primarily
through
the high-affinity LDL receptor. Clinical and pathologic
studies
wshow that elevated plasma levels of total cholestero
(total-C), LDL-cholesterol (LDL-C), and apolipoprotein B
(apo B)
promote
human atherosclerosis and are risk factors for
developing cardiovascular disease, while increased
levels of
HDL-C
are associated with a decreased cardiovascular risk.
In
animal models, Atorvastatin (Lipitor) lowers plasma
cholesterol
and
lipoprotein levels by inhibiting HMG-CoA reductase
and
cholesterol synthesis in the liver and by increasing the
number of
hepatic
LDL receptors on the cell-surface to enhance uptake and
catabolism of LDL; Atorvastatin (Lipitor) also reduces
LDL
production and the number of LDL particles. Atorvastatin
(Lipitor)
reduces
LDL-C in some patients with homozygous familial
hypercholesterolemia (FH), a population that rarely
responds to
other
lipid-lowering medication.
A
variety of clinical studies have demonstrated that
elevated levels
of
total-C, LDL-C, and apo B (a membrane complex for LDL-C)
promote
human atherosclerosis. Similarly, decreased levels of
HDL-C
(and its transport complex, apo A) are associated with
the
development of atherosclerosis. Epidemiologic
investigations
have
established that cardiovascular morbidity and mortality
vary
directly
with the level of total-C and LDL-C, and inversely with
the
level of
HDL-C. Although frequently found in association with low
HDL-C,
elevated plasma TG has not been established as an
independent risk factor for coronary heart disease. The
independent effect of of raising HDL-C or lowering TG on
the risk
fro
coronary and cardiovascular morbidity and mortality has
not
been
established.
Atorvastatin (Lipitor) reduces total-C, LDL-C, and apo B
in patients
with
homozygous and heterozygous FH, nonfamilial forms of
hypercholesterolemia, and mixed dyslipidemia.
Atorvastatin
(Lipitor)
also reduces VLDL-C and TG and produces variable
increases in HDL-C and apolipoprotein A-1. The effect of
Atorvastatin (Lipitor) on cardiovascular morbidity and
mortality has
not been
determined.
Like LDL,
cholesterol-enriched triglyceride-rich lipoproteins,
including VLDL, intermediate density lipoprotein (IDL),
and
remnants, can also promote atherosclerosis. Elevated
plasma
triglycerides are frequently found in a triad with low
HDL-C levels
and
small LDL particles, as well as in association with
non-lipid
metabolic risk factors for coronary heart disease. As
such, total
plasma
TG has not consistently been shown to be an
independent risk factor for CHD. Furthermore, the
independent
effect
of raising HDL or lowering TG on the risk of coronary
and
cardiovascular morbidity and mortality has not been
determined.
Dosage:
As per the physician’s advice.
Presentations:
MRP Retailer Stockist
10 tablets 25.20
20.16 18.14
10 tablets 49.50
39.60 35.64
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