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Ear
Drops
Composition:
Gentamicin I.P.............................................................
0.3% w/v
Clotrimazole..................................................................1%
w/v
Betamethasone Depropionate U.S.P.......................0.025%
w/v
Lignocaine HCL............................................................2%
w/v
In
glycerin I.P & Propylene Glycol I.P............................q.s.
Indications :
Gentabet can
cause severe hearing and kidney problems. Gentabet
eliminates bacteria that cause many kinds of infections,
including lung, skin, bone, joint, stomach, blood, and
urinary tract infections.
Description:
The binding
of gentamicin (Gm) to Escherichia coli ribosomes and
ribosomal subunits has been studied. By means
of equilibrium dialysis and of statistical
interpretation of the data it was found that
[3H]gentamicin C2 and
6'-N-[3H]methylgentamicin C1a interact with three
classes of sites on tight-coupled 70-S
species: a first class concerning the tight and
non-cooperative interaction with one drug molecule
(Kd = 0.6 microM), a second class in which
about five Gm molecules bind cooperatively (mean Kd =
10 microM), and a third class of very high
capacity in which up to 70 drug molecules may
interact. The extreme cooperativity of the third class
of sites induces such an increase in the
affinity for Gm that it may allow the shift
of molecules already bound from high-affinity sites
towards lower-affinity sites. The alteration
of a ribosomal protein, L6, in a gentamicin-
resistant mutant of E. coli abolished the multiclass and
the cooperative aspects of
ribosomes--gentamicin interaction.
The large ribosomal subunits from E. coli MRE
600 strain interact cooperatively with Gm,
whereas 50-S particles from the resistant mutant bind
the drug in a diffuse way with high capacity
and low affinity. The small subunits from
both strains behave identically towards Gm. A good
correlation is observed in comparing the
gentamicin concentrations capable of saturating the
different ribosomal classes of sites with
concentrations inducing its multiphasic
effects on protein synthesis.
Dosage: As per
the physician’s advice.
Presentations:
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