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Each
tablet contains:
Composition:
Gatifloxacin.....................................................................200
mg
Ornidazole......................................................................500
mg
Indications:
·
Respiratory tract infections like lung abscess,
aspiration pneumonia, empyema and bronchiectasis.
·
ENT
infections like chronic sinusitis, chronic suppurative
otitis media, cholesteatoma and mastoiditis.
·
Dermatological infections like cellulitis, breast and other
cutaneous abscesses, gangrene and decubitus ulcers.
Orofacial and dental infections.
·
Surgical wound infections.
·
Gynaecological infections including
Description:
Gatifloxacin, a new type of quinolone antibiotic, has
been approved by the U.S. Food and Drug Administration
for indications including the treatment of
community-acquired respiratory tract infections (RTIs).
It was designed with a unique 8-methoxy structure that
appears to enhance bactericidal action and decrease the
rate of the development of resistance of gram-positive
bacteria.
Quinolones rapidly inhibit DNA synthesis by promoting
cleavage of bacterial DNA in the DNA-enzyme complexes of
DNA gyrase and type IV topoisomerase, resulting in rapid
bacterial death. As a general rule, gram-negative
bacterial activity correlates with inhibition of DNA
gyrase, and gram-positive bacterial activity corresponds
with inhibition of DNA type IV topoisomerase.
Quinolones inhibit two specific enzymes, DNA gyrase and
DNA topoisomerase IV, which aid in bacterial DNA
replication. FACTIVE displays strong binding affinity at
both of these target sites, which helps maintain high in
vitro potency against resistant
S pneumoniae.
This dual targeting with FACTIVE is achievable at
therapeutic drug levels.
The antimicrobial activity of ornidazole is due
to the reduction of the nitro group to a more reactive
amine that attacks microbial DNA, brings about loss of
helical structure of DNA and subsequent DNA breakage
thus inhibiting further synthesis and causing
degradation of existing DNA.
contraindications
Gatifloxacin is contraindicated in persons with a
history of
hypersensitivity
to gatifloxacin or any
member of the
quinolone
class of
antimicrobial
agents.
Ornidazole
is contraindicated in persons with a
history of
hypersensitivity
ornidazole and other imidazoles.
Warnings and precautions
Special precautions are required in case of ataxia,
vertigo, mental confusion and patients with neurological
diseases. There is need for adjustment of dosage and
dosage interval in patients with hepatic impairment.
Modification of the usual dosage is not necessary in
patients of renal failure however, additional post
haemodialysis dose may be required in patients
undergoing this procedure. ]
Dosage:
The
recommended dosage for Gatimin-OZ tablets is described
below. Doses of Gatimin-OZ are administered once every
24 hours.
Presentations: 10 tablets
MRP
Retailer
Stockist
45.00
36.00
32.40
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