|
5ml/10ml Ear Drops
Composition:
Paradichlorobenzene............................................2
%
Benzocaine...........................................................2.7
%
Chlorbutol................................................................5%
Terpentine
Oil.......................................................15%
Indications:
Benotol
is used in the ear to help relieve the pain, swelling,
and congestion of some ear infections. It will not cure
the infection itself. An antibiotic will be needed to
treat the infection.
Description:
Local anesthetic drugs act mainly by inhibiting
sodium influx
through sodium-specific
ion channels
in the
neuronal
cell membrane,
in particular the so-called voltage-gated sodium
channels. When the influx of sodium is interrupted, an
action potential
cannot arise and signal conduction is inhibited. The
receptor site is thought to be located at the
cytoplasmic (inner) portion of the sodium channel. Local
anesthetic drugs bind more readily to "open" sodium
channels, thus onset of neuronal blockade is faster in
neurons that are rapidly firing. This is referred to as
state dependent blockade.
Local anesthetics are weak
bases and are
usually formulated as the hydrochloride salt to render
them water-soluble. At physiologic
pH the
protonated (ionised) and unprotonated (unionised) forms
of the molecule exist in an equilibrium but only the
unprotonated molecule diffuses readily across cell
membranes. Once inside the cell, the lower pH results in
the molecule being protonated, thus inhibiting its
passage back out of the cell. This is referred to as
"ion-trapping". In the protonated form, the molecule
binds to the local anaesthetic binding site on the
inside of the ion channel near the cytoplasmic end.
Acidosis such as caused by wound infection partly
reduces the action of local anesthetics. This is partly
because most of the anaesthetic is ionised and therefore
unable to cross the cell membrane
CONTRAINDICATIONS
Known allergy or hypersensitivity to benzocaine.
Dosage: As per the physician’s advice.
Presentations:
MRP Retailer Stockiest
21.98 17.58 15.82
| 
